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KMID : 0376219920290010039
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Chonnam Medical Journal
1992 Volume.29 No. 1 p.39 ~ p.46
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Clinical usefulness of C-peptide measurement in non-insulin-dependent diabetes mellitus(NIDDM)
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Abstract
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To clarify whether the insulin secretory function of pancreatic β-cell improves after control of blood sugar levels with insulin therapy, fasting and postprandial serum C-peptide concentrations were measured before and after insulin treatment in
16
uncontrolled NIDDM patients.
@ES The results were as follows;
@EN 1) After insulin treatment, fasting blood sugar levels decreased from 227.7±14.5mg/dl(mean±SE) to 153.7±12.6mg/dl and postprandial blood sugar levels from 306.6±15.4mg/dl to 226.2±15.4mg/dl(P<0.001, respectively).
2) Fasting (1.83±0.27ng/ml VS 1.61±0.19ng/ml) and pastprandial serum C-peptide coccentrations(2.42±0.37ng/ml VS 2.47±0.28ng/ml) were not changed by insulin treatment.
3) Glucose potentiation effect on insulin response (△CPR/△BS×BS×100) were not changed with insulin treatment (1.10±0.55 VS 0.88±0.47), but the ratio of postprandial C-peptide to postprandial blood sugar levels (CPR/BS×100) increased from
0.81±0.12 to 1.19±0.18(P<0.01).
4) Above results suggest that pancreatic β-cell function could be assessed by simultaneous measurement of C-peptide and glucose levels in peripheral blood, and it could be improved after control of blood sugar levels with insulin treatment.
Keywords: C-peptide, β-cell function, non-insulin-dependent diabetes mellitus
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KEYWORD
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